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KMID : 0811720120160040249
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Korean Journal of Physiology & Pharmacology
2012 Volume.16 No. 4 p.249 ~ p.253
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The Safety and Pharmacokinetics of Cyanidin-3-Glucoside after 2-Week Administration of Black Bean Seed Coat Extract in Healthy Subjects
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Jeon Sang-Il
Han Seung-Hoon
Lee Jong-Tae
Hong Tae-Gon
Yim Dong-Seok
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Abstract
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We analyzed the pharmacokinetics of C3G on data from twelve subjects, after 2-week multiple dosing of black bean (Phaseolus vulgaris, Cheongjakong-3-ho) seed coat extract, using the mixed effect analysis method (NONMEM, Ver. 6.2), as well as the conventional non-compartmental method. We also examined the safety and tolerability. The PK analysis used plasma concentrations of the C3G on day 1 and 14. There was no observed accumulation of C3G after 2-week multiple dosing of black bean seed coat extract. The typical point estimates of PK were CL (clearance)=3,420 l/h, V (volume)=7,280 L, Ka (absorption constant)=9.94 h－1, ALAG (lag time)=0.217 h. The black bean seed coat extract was well tolerated and there were no serious adverse events. In this study, we confirmed that a significant amount of C3G was absorbed in human after given the black bean seed coat extract.
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KEYWORD
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Anthocyanin, Clinical trial, C3G, Pharmacokinetics, Phaseolus vulgaris
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